REVIEW PAPER
Local transfer of substances between the blood vessels at the base of the brain
J. Skipor 1  
,   N. Einer-Jensen 2
 
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1
Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-747 Olsztyn, Poland
2
Physiology and Pharmacology, IMB, University of Southern Denmark, 5230 Odense M, Denmark
CORRESPONDING AUTHOR
J. Skipor   

Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, Tuwima 10, 10-747 Olsztyn, Poland
Publication date: 2006-11-06
 
J. Anim. Feed Sci. 2006;15(4):543–553
 
KEYWORDS
ABSTRACT
Studies performed on a variety of species (pigs, sheep, rabbits, rats) indicate the existence of a local transfer system of substances between blood vessels located at the base of the cranium (the cavernous sinus - carotid artery vascular complex). This local transfer allows for some hormones synthesized in the brain and hypophysis, as well as biologically active substances absorbed from the nasal mucosa, and drained to the cavernous sinus to reach the brain vasculature in a concentration locally higher than that measured in systemic circulation. The present paper gives an overview of: 1. the major anatomical structure engaged in the transfer, 2. experimental evidence for substance transfer in the vascular complex, 3. factors affecting the transfer and 4. possible physiological importance.
 
CITATIONS (3):
1.
Comparative study of formation of circle of Willis in human and sheep brain
S. Deepthi, D. Suseelamma, D. Pramod Kumar, S.S. Saradadevi, V. Subhadradevi
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2.
A New Technique and Device for Controlled and Continuous Drug Delivery into the Brain – A Proof of Concept Study
U.R Anoop, Kavita Verma
 
3.
New technique and device for controlled and continuous drug delivery into the brain: a proof-of-concept study
R U, Kavita Verma
BMJ Innovations
 
ISSN:1230-1388