0.857
IF5
0.900
IF
Q3
JCR
0.92
CiteScore
0.405
SJR
Q2
SJR
20
MNiSW
165.24
ICV
REVIEW PAPER
 
CC-BY 4.0
 
 

Effect of high doses of L-ascorbic acid on the antioxidative/oxidative state in the rats

T. Niemiec 1  ,  
E. Sawosz 1,  
 
1
Warsaw Agricultural University, Department of Animal Nutrition and Feed Science, Ciszewskiego 8, 02-786 Warszawa, Poland
2
The Royal Veterinary and Agricultural University, Department of Animal and Veterinary Basic Sciences, Bülowsvej 13, Frederiksberg C, Denmark
J. Anim. Feed Sci. 2005;14(Suppl. 1):553–556
Publish date: 2005-06-26
KEYWORDS:
ABSTRACT:
The objective of this study was to determine the effects of mega-doses of vitamin C (0.3, 0.6 and 0.9% of diet) as a dietary supplement for rats on selected indices of the antioxidative/oxidative state in 40 growing Wistar rats (4 × 10). It was found that L-ascorbic acid and Total Antioxidative State (TAS) in plasma did not increase with increasing vitamin C supply. The results indicate that high doses of L-ascorbic acid (0.3 and 0.9 but not 0.6%) increased the concentration of this antioxidant in plasma. Supplementation of vitamin C above 0.3% to the diets had pro-oxidative effects on lipid structures, while application of 0.9% promoted oxidative degradation of rat livers.
CORRESPONDING AUTHOR:
T. Niemiec   
Warsaw Agricultural University, Department of Animal Nutrition and Feed Science, Ciszewskiego 8, 02-786 Warszawa, Poland
ISSN:1230-1388