REVIEW PAPER
Effect of high doses of L-ascorbic acid on the antioxidative/oxidative state in the rats
T. Niemiec 1  
,   E. Sawosz 1,   A. Chwalibog 2
 
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1
Warsaw Agricultural University, Department of Animal Nutrition and Feed Science, Ciszewskiego 8, 02-786 Warszawa, Poland
2
The Royal Veterinary and Agricultural University, Department of Animal and Veterinary Basic Sciences, Bülowsvej 13, Frederiksberg C, Denmark
CORRESPONDING AUTHOR
T. Niemiec   

Warsaw Agricultural University, Department of Animal Nutrition and Feed Science, Ciszewskiego 8, 02-786 Warszawa, Poland
Publication date: 2005-06-26
 
J. Anim. Feed Sci. 2005;14(Suppl. 1):553–556
 
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ABSTRACT
The objective of this study was to determine the effects of mega-doses of vitamin C (0.3, 0.6 and 0.9% of diet) as a dietary supplement for rats on selected indices of the antioxidative/oxidative state in 40 growing Wistar rats (4 × 10). It was found that L-ascorbic acid and Total Antioxidative State (TAS) in plasma did not increase with increasing vitamin C supply. The results indicate that high doses of L-ascorbic acid (0.3 and 0.9 but not 0.6%) increased the concentration of this antioxidant in plasma. Supplementation of vitamin C above 0.3% to the diets had pro-oxidative effects on lipid structures, while application of 0.9% promoted oxidative degradation of rat livers.
 
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1.
Neurotoxic effect of the herbicide paraquat on ascidian larvae
Giuliana Zega, Simona Candiani, Silvia Groppelli, Bernardi De, Roberta Pennati
Environmental Toxicology and Pharmacology
 
ISSN:1230-1388