ORIGINAL PAPER
Antidiabetic effect of black pepper, turmeric, and ajwa date pulp,
seed, and their mixtures as antioxidants in alloxan diabetic rats
1
University of Agriculture Faisalabad, Department of Zoology, Wildlife and Fisheries, Sub Campus Toba Tek Singh, 36050, Pakistan
2
University of Agriculture Faisalabad, Institute of Physiology and Pharmacology, Faisalabad 38000, Pakistan
3
University of Okara, Department of Chemistry, Okara 56300, Punjab, Pakistan
4
The Islamia University of Bahawalpur, Department of Agronomy, Faculty of Agriculture and Environment, Bahawalpur 63100, Pakistan
5
The Islamia University of Bahawalpur, Department of Eastern Medicine, Faculty of Medicine and Allied Health Sciences,
Bahawalpur 63100, Pakistan
6
University of Tabuk, Alwajh College, Department of Chemistry, Tabuk 71491, Saudi Arabia
7
University of Tabuk, Department of Biochemistry, College of Science, Tabuk 71491, Saudi Arabia
8
Jazan University, Department of Clinical Nutrition, Applied Medical Science, Jazan 45142, Saudi Arabia
9
Helwan University, College of Home Economic, Food and Science Department, Cairo 11795 Egypt
10
King Abdul Aziz University, Faculty of Human Sciences and Design, Department of Food and Nutrition,
P.O. Box 42807, Jeddah 21551, Saudi Arabia
11
King Saud bin Abdulaziz University for Health Sciences, College of Applied Medical Sciences, Clinical Nutrition Department,
P.O. Box 2477, Al Ahsa 31982, Saudi Arabia
12
King Saud bin Abdulaziz University for Health Sciences, Department of Pediatrics, College of Medicine, Riyadh, Saudi Arabia
13
University of Tabuk, Department of Food Science and Nutrition, Faculty of Science, Tabuk 71491, Saudi Arabia
14
Shaheed Benazir Bhutto University Sheringal, Department of Environmental Sciences, Dir (U), Khyber Pakhtunkhwa 18000, Pakistan
15
The University of Western Australia, School of Biological Sciences, 35 Stirling Highway, Perth, WA 6009, Australia
Publication date: 2023-09-04
Corresponding author
M. Sarfraz
University of Agriculture Faisalabad, Department of Zoology, Wildlife and Fisheries, Sub Campus Toba Tek Singh, 36050, Pakistan
University of Agriculture Faisalabad, Department of Zoology, Wildlife and Fisheries, Sub Campus Toba Tek Singh, 36050, Pakistan
A. Ditta
Shaheed Benazir Bhutto University Sheringal, Department of Environmental Sciences, Dir (U), Khyber Pakhtunkhwa 18000, Pakistan
Shaheed Benazir Bhutto University Sheringal, Department of Environmental Sciences, Dir (U), Khyber Pakhtunkhwa 18000, Pakistan
J. Anim. Feed Sci. 2024;33(1):28-46
KEYWORDS
TOPICS
ABSTRACT
Testing natural antihyperlipidemic substances is necessary due
to the increasing prevalence of diabetes mellitus, which leads to chronic hyperglycaemia
and poses a significant threat to public health and well-being
worldwide. The present study investigated the anti-diabetic effect of black pepper,
turmeric, and ajwa date pulp + seed and their mixtures as hypolipidemic,
antioxidant and protective agents on the liver and kidney by examining histological
changes in alloxanised diabetic rats. Eleven groups consisting of eighteen
males and eighteen females were divided into a normal control (nondiabetic),
a positive control (diabetic), positive groups receiving glibenclamide
(10 mg kg-1 body weight), black pepper (BP), turmeric (T), ajwa pulp (AP), ajwa
seeds (AS) aqueous extracts and their various combinations. The dose of BP aqueous
extract was 50 mg kg-1 body weight, while the dose of the other materials was
500 mg kg-1 body weight. The aqueous extracts were administered orally once
daily for eight weeks. Our phytochemical screening detected the presence of flavonoids,
tannins, saponins, steroids, and alkaloids in these extracts. The results
pertaining to serum levels of glucose, lipids, glycosylated haemoglobin, and antioxidant
biomarkers revealed significant improvements after administration of AS,
BP + AS, and the mixture of all extracts. Moreover, histological analyses demonstrated
the protective effects of these extracts. In conclusion, all tested materials,
especially ajwa seeds administered alone and in combination with black pepper
extract, exerted significant antihyperlipidemic and weight-stabilising effects in
alloxanised diabetic rats. Therefore, these natural substances hold promise as
potential herbal medicines for managing diabetes mellitus.
CONFLICT OF INTEREST
The Authors declare that there is no conflict of
interest.
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