0.857
IF5
0.900
IF
Q3
JCR
0.92
CiteScore
0.405
SJR
Q2
SJR
20
MNiSW
165.24
ICV
SHORT COMMUNICATION
 
CC-BY 4.0
 
 

Splanchnic net balance of oxygen and metabolites in response to mesenteric vein infusion of ammonia in sheep

M. I. Recavarren 1  ,  
 
1
Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro, Campus Universitario, 7000, Tandil, Buenos Aires, Argentina
J. Anim. Feed Sci. 2004;13(Suppl. 1):335–338
Publish date: 2004-08-30
KEYWORDS
ABSTRACT
In order to simulate daily episodes of high ammonia (NH4+) absorption associated with the intake of diets with high content of non-protein N or rapidly rumen degradable protein, four wethers (42±3.4 kg BW), surgically fitted with indwelling catheters in the posterior aorta and splanchnic veins, were infused with 340 µmol NH4+HCO3-/min into the mesenteric vein for 3 h, over 7 consecutive days. On the 7th day, net mass transfers of NH4+, urea, glucose, lactate, ß-OH-butyrate and oxygen were measured across portal-drained viscera (PDV), liver and splanchnic tissues during the last 90 min of the NH4+ infusion (NH4+ treatment, AT). Measurements were repeated on the following day, after withdrawal of the NH4+ infusion (Control treatment, CT). NH4+ infusion increased liver NH4+ uptake (+396 µmol/min; sed, 72; P=0.04) and urea production (+152 µmol/min; sed, 55; P=0.14), and oxygen consumption by the liver (+151 µmol/min; sed, 6; P=0.002), the PDV (+224 µmol/min; sed, 56; P=0.03) and the splanchnic tissues (+352 µmol/min; sed, 57; P=0.009). Net mass transfers of glucose, lactate and ß-OH-butyrate across the PDV and the liver, and the acid-base status of the animals were unchanged.
CORRESPONDING AUTHOR
M. I. Recavarren   
Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro, Campus Universitario, 7000, Tandil, Buenos Aires, Argentina
ISSN:1230-1388