ORIGINAL PAPER
Photoperiodic conditions as a factor modulating leptin influence
on pro-inflammatory cytokines
and their receptors gene expression in ewe’s aorta
1
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Department of Genetic Engineering, Instytucka 3, 05-110 Jabłonna
2
Agricultural University of Krakow, Department of Animal Biotechnology, Laboratory of Biotechnology and Genomics, 30-248 Krakow, Poland
Publication date: 2019-06-19
Corresponding author
A. Krawczyńska
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Department of Genetic Engineering, Instytucka 3, 05-110 Jabłonna
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, Department of Genetic Engineering, Instytucka 3, 05-110 Jabłonna
J. Anim. Feed Sci. 2019;28(2):128-137
KEYWORDS
TOPICS
ABSTRACT
Atherosclerosis, a chronic inflammation state of the aorta, is
characterised by increased levels of pro-inflammatory cytokines (tumour
necrosis factor alpha (TNFα), interleukin (IL)-1β, IL-6). Sheep is used in both
cardiovascular and immunological studies; besides, ‘long-day’ ewe can be
a model of leptin resistance state. The aim of the study was to examine whether
photoperiodic conditions (long-day (LD) and short-day (SD) seasons) are a key
factor modulating exogenous leptin influence on pro-inflammatory cytokines and
their receptors gene expression in aorta of ewe’s with or without prior induction
of acute inflammation. The experiment was conducted on 48 ewes during SD
and LD seasons which were randomly divided into 4 groups: control; with LPS
injection (400 ng/kg of body weight (BW)); with leptin injection (20 μg/kg BW);
and with LPS and 30-min later leptin injection. Three hours after LPS/control
treatment animals were euthanized to collect the thoracic aorta samples. In
both seasons leptin injection intensified LPS-induced increase in IL1B gene
expression but only in SD season leptin injection increased IL1R1 and IL1R2
gene expressions. The leptin injection increased IL6 gene expression but only
in SD season. In the LD season leptin enhanced the LPS effect on IL6 gene
expression. Neither TNFA nor its receptors gene expression was influenced by
leptin regardless of season. In the thoracic aorta tissue an exogenous leptin
exerts effect on pro-inflammatory cytokines and their receptors gene expression;
however in ewe this influence depends on photoperiodic conditions. Moreover,
leptin can moderate progression of the inflammation reaction in this tissue
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