SHORT COMMUNICATION
Effects of pentagastrin and IGF-1 on DNA synthesis
of rumen epithelial cells of dairy cow
and neonatal calf
1
Lab of Animal Physiology and Biochemistry, Nanjing Agricultural University,
Weigang, Nanjing 210095, China
Publication date: 2004-08-30
Corresponding author
Z. Shen
Lab of Animal Physiology and Biochemistry, Nanjing Agricultural University, Weigang, Nanjing 210095, China
Lab of Animal Physiology and Biochemistry, Nanjing Agricultural University, Weigang, Nanjing 210095, China
J. Anim. Feed Sci. 2004;13(Suppl. 1):289-292
KEYWORDS
ABSTRACT
Pentagastrin (PG) (10-12, 10-11, 10-10and 10-9 mol/L) and IGF-1 (25 and 50 µg/L) increased DNA
synthesis of rumen epithelial cell (REC) of dairy cows in a dose dependent manner by approximately
30-40% and 13% (P<0.05), respectively. Proglumide (gastrin/CCK B receptor blocker) abolished
the trophic action of PG, which indicates that the positive effect of PG on REC is probably mediated
by the gastrin receptor. REC of neonatal calves did not response to PG. However, IGF-1, at all given
doses (25-200 µg/L), promoted DNA synthesis in REC of neonatal calves (P<0.05).
CITATIONS (2):
1.
Elevated cyclin D1 expression is governed by plasma IGF-1 through Ras/Raf/MEK/ERK pathway in rumen epithelium of goats supplying a high metabolizable energy diet
J. Lu, H. Zhao, J. Xu, L. Zhang, L. Yan, Z. Shen
Journal of Animal Physiology and Animal Nutrition
J. Lu, H. Zhao, J. Xu, L. Zhang, L. Yan, Z. Shen
Journal of Animal Physiology and Animal Nutrition
2.
Establishment of Immortalized Yak Ruminal Epithelial Cell Lines by Lentivirus-Mediated SV40T and hTERT Gene Transduction
JunMei Wang, Rui Hu, Zhisheng Wang, Yixin Guo, Sen Wang, Huawei Zou, Quanhui Peng, Yahui Jiang, Kai Wang
Oxidative Medicine and Cellular Longevity
JunMei Wang, Rui Hu, Zhisheng Wang, Yixin Guo, Sen Wang, Huawei Zou, Quanhui Peng, Yahui Jiang, Kai Wang
Oxidative Medicine and Cellular Longevity
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