ORIGINAL PAPER
Effect of dietary organic selenium (Se) on immune response, hepatic antioxidant status, selenoprotein gene expression and meat oxidative stability in lambs
1
ICAR-National Institute of Animal Nutrition and Physiology, Indian Council of Agricultural Research, Adugodi, Bangalore, Karnataka 560030, India
2
ICAR-National Institute of Veterinary Epidemiology and Disease Informatics, Indian Council of Agricultural Research,
Bangalore, Karnataka 560 064, India
Publication date: 2019-05-31
Corresponding author
R. U. Suganthi
ICAR-National Institute of Animal Nutrition and Physiology, Indian Council of Agricultural Research, Adugodi, Bangalore, Karnataka 560030, India
ICAR-National Institute of Animal Nutrition and Physiology, Indian Council of Agricultural Research, Adugodi, Bangalore, Karnataka 560030, India
J. Anim. Feed Sci. 2019;28(2):138-148
KEYWORDS
TOPICS
ABSTRACT
The objective of the study was to examine the effects of different
doses of dietary organic selenium (Se) on humoral immune response, hepatic
antioxidant status, mRNA expression of key selenoproteins and oxidative stability of lamb meat. Twenty lambs aging 5–6 months received during a 90-day period a basal diet unsupplemented or supplemented with 0.5, 1.5 or 4.5 ppm Se
(selenized yeasts). After experimental period, immune response against Peste
des petits ruminants (PPR) virus vaccine, hepatic antioxidant status, selenoproteins gene expression, histology of liver, kidney, spleen and thymus, and meat
oxidative stability after 0, 3, 7 and 10 days of storage were studied. Significantly
higher serum PPR antibody titre and hepatic total antioxidant capacity in lambs
fed diet supplemented with 1.5 and 4.5 ppm Se were shown. Gene expression
of glutathione peroxidase 1 (GPX1) and GPX3 was increased in group with 0.5
ppm Se supplementation. While selenoprotein 15 and iodothyronine deiodinase
1 (DIO1) mRNA levels were not influenced by supranutritional Se supplementation, DIO3 mRNA level was upregulated at 4.5 ppm Se addition. Selenoprotein P
and W1 gene expression were significantly upregulated by 1.5 and 4.5 ppm Se
supplementation, respectively. Thioredoxin reductase 1 gene expression was
decreased by 4.5 ppm Se. No appreciable differences in meat lipid oxidation
were observed amongst treatments. So, feeding 1.5 ppm organic Se could be
beneficial in improving humoral immune response to PPR vaccine and hepatic
antioxidant status in lambs. Further, the expression of genes encoding selenoproteinases depends on their type and dose of Se in the diet. The studied Se
doses did not induce toxicity in organs but exhibited limited potential to enhance
meat oxidative stability.
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