SHORT COMMUNICATION
Alpha-ketoglutarate reduces duodenal myoelectric disturbances induced by E. coli enterotoxin in pigs
G. Yao 1
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1
The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland
 
 
Publication date: 2005-06-21
 
 
Corresponding author
M. Ceregrzyn   

The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 05-110 Jabłonna, Poland
 
 
J. Anim. Feed Sci. 2005;14(Suppl. 1):417-420
 
KEYWORDS
ABSTRACT
Pigs with bipolar electrodes implanted on the antrum and duodenum were exposed to heat-labile enterotoxin from E. coli (LT) infused intraduodenally. The exposure was repeated after three days of supplementing feed with α-ketoglutarate (AKG). 0.5 µg/kg of LT induced prolonged changes in the migrating myoelectric complex (MMC) without inducing clinical signs of enterotoxaemia. AKG had no effect on the basic MMC pattern, but prevented LT-induced changes. The possible mechanism of AKG and LT-induced alteration may involve gamma-aminobutyric acid (GABA) synthesis and activation of GABAergic neurotransmission in the gut.
ISSN:1230-1388
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